Published Research About The Role of Oxidative Stress In Keratoconus

Our Formula Was Designed Around The Findings of the Following Studies:

OUR INGREDIENTS LIST

(And Their Functions in the Body)

Vitamins A,C,E { Common and Powerful Antioxidant Nutrients to Combat the Oxidative Changes that Drive Keratoconus Progression}

Zinc and Selenium { Have Antioxidant Functions and Serve as Cofactors in Collagen Synthesis To Support Repair of Corneal Tissue}

Copper { An Extremely Important Micronutrient that is Hard to Obtain in Diet that Is Found to Help Interfere With the Inflammatory Changes That Make Keratoconus Worse}

L-Glutathione { A Chemical that is Found in High Levels in the Normal Cornea that are in Very Low Amounts in Patients With Keratoconus}

N-Acetylcysteine { Found to Be An Important Co-Factor in Corneal Protection Against Oxidative Damage}

Scientific Studies Showing The Value of the Above Nutrients to Corneal Protection in Keratoconus

Oxidative stress in keratoconus? - ‎Arnal - Cited by 95

… response to oxidative stress in keratoconus corneal … - ‎Chwa - Cited by 72

in keratoconus corneas: evidence that oxidative stress … - ‎Kenney - Cited by 171

Oxidative stress in keratoconus? - NCBI

 

https://www.ncbi.nlm.nih.gov/pubmed/21969298

by E Arnal - ‎2011 - ‎Cited by 94 - ‎Related articles

Nov 4, 2011 - CONCLUSIONS: The increased levels of oxidative stress markers and the decreased antioxidant capacity and antioxidant defenses in KC corneas, as well as in the post-LASIK ectatic corneas, indicate that oxidative stress might be involved in the development of this disease and may provide new insights for its prevention ...

Oxidative stress induces dysregulated autophagy in corneal ... - NCBI

 

https://www.ncbi.nlm.nih.gov/pubmed/28902914

by R Shetty - ‎2017 - ‎Cited by 8 - ‎Related articles

Sep 13, 2017 - Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients. Shetty R(1), Sharma A(2), Pahuja N(1), ...

Oxidative Stress in the Pathogenesis of Keratoconus and Fuchs ...

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794834/

by KA Wojcik - ‎2013 - ‎Cited by 70 - ‎Related articles

Sep 23, 2013 - UV produces reactive oxygen species (ROS) which render the cornea particularly susceptible to oxidative stress as a consequence of an imbalance between ROS production and antioxidant capacity of the cell [1]. Therefore, oxidative stress reflects increased production and/or impaired removal of ROS.

Abstract · ‎Introduction · ‎Oxidative Stress · ‎Conclusions

Oxidative Stress May Contribute to Keratoconus - Review of Optometry

 

https://www.reviewofoptometry.com/.../oxidative-stress-may-contribute-to-keratoconu...

Aug 28, 2018 - Oxidative Stress May Contribute to Keratoconus. Supplementing with zinc, copper and selenium could possibly augment current therapy.

(PDF) Oxidative Stress in Keratoconus? - ResearchGate

 

https://www.researchgate.net/publication/51690964_Oxidative_Stress_in_Keratoconus

PDF | The purpose of this study was to establish the alterations of oxidative stress-related markers inkeratoconus (KC) corneas. A total of 6 healthy and 11 ...

Oxidative Stress in Keratoconus? | IOVS | ARVO Journals

 

https://iovs.arvojournals.org/article.aspx?articleid=2186731

by E Arnal - ‎2011 - ‎Cited by 94 - ‎Related articles

The increased levels of oxidative stress markers and the decreased antioxidant ... Keratoconus (KC) is a significant clinical problem worldwide and a leading ...

Hypersensitive Response to Oxidative Stress in Keratoconus Corneal ...

 

https://iovs.arvojournals.org/article.aspx?articleid=2125588

by M Chwa - ‎2008 - ‎Cited by 72 - ‎Related articles

purpose. It is unclear whether the oxidative damage found in keratoconus (KC) corneas results from innate defects of corneal fibroblasts or is due to excessive ...

Sulforaphane protects rabbit corneas against oxidative stress injury in ...

 

https://www.spandidos-publications.com/ijmm/42/5/2315

by R Liu - ‎2018 - ‎Cited by 1 - ‎Related articles

Aug 10, 2018 - Keratoconus (KC) is the leading cause of eye blindness. ... Under oxidative stressconditions, Nrf-2 is dissociated from Keap1, constitutively ...

Genetics, oxidative stress suspected causes of keratoconus - Healio

 

https://www.healio.com/.../genetics-oxidative-stress-suspected-causes-of-keratoconus

Primary Care Optometry News | COLUMBUS, Ohio — While the treatment of keratoconus is fairly straightforward, with well-fitted specialty lenses or corneal ...

In vitro model suggests oxidative stress involved in keratoconus disease

 

https://www.nature.com › scientific reports › articles

by D Karamichos - ‎2014 - ‎Cited by 48 - ‎Related articles

Apr 9, 2014 - We aimed to identify oxidative stress levels between human corneal keratocytes (HCKs), fibroblasts (HCFs) and keratoconus cells (HKCs).

Increased systemic oxidative stress in patients with keratoconus | Eye

 

https://www.nature.com › eye › clinical study

by I Toprak - ‎2014 - ‎Cited by 37 - ‎Related articles

Dec 6, 2013 - To establish the effect of systemic oxidative stress on the pathogenesis of keratoconusby measuring serum total oxidant status (TOS) and total ...[PDF]

Tear Film and Serum Prolidase Activity and Oxidative Stress in ...

 

www.smo.org.mx/archivos/smonline/cornea/articulos/1019–1023.pdf

prolidase activity (PA) between patients with keratoconus and healthy subjects. Also, we aimed to evaluate the serum oxidative stress level and the correlation ...

Oxidative Stress in the Pathogenesis of Keratoconus and Fuchs ...

 

https://www.semanticscholar.org/.../Oxidative-Stress...Keratoconus.../db5a79e5fa3138fd...

Therefore, corneal cells are particularly susceptible to oxidative stress. ... Keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD) are multifactorial ...

Evidence of Oxidative Stress in Human Corneal Diseases - Rajeev ...

 

https://journals.sagepub.com/doi/full/10.1177/002215540205000306

by R Buddi - ‎2002 - ‎Cited by 273 - ‎Related articles

Keratoconus corneas showed evidence of oxidative damage from cytotoxic byproducts generated by lipid peroxidation and the NO pathway. Bullous keratopathy ...

Oxidative Stress and keratoconus : Keratoconus - Reddit

 

https://www.reddit.com/r/Keratoconus/comments/.../oxidative_stress_and_keratoconus...

Feb 11, 2019 - 1 post - ‎1 author

Welcome to the largest Keratoconus support community on the web. Here you can share yourkeratoconus stories, ask for recommendations, ...

Nrf2, a Potential Therapeutic Target against Oxidative Stress in ...

 

https://www.hindawi.com/journals/omcl/2017/2326178/

by XF Liu - ‎2017 - ‎Cited by 3 - ‎Related articles

Sep 20, 2017 - A Nrf2-Keap1-dependent protective role against oxidative stress in ... as Fuchs endothelial corneal dystrophy (FECD) and keratoconus [23].

Novel Assay Assessment of Oxidative Stress Biomarkers in Patients ...

 

https://www.tandfonline.com/doi/abs/10.1080/02713683.2017.1302592

by B Gulpamuk - ‎2017 - ‎Cited by 2 - ‎Related articles

Purpose: To investigate systemic oxidative stress by evaluating thiol–disulfide homeostasis using a novel automated homeostasis assay in keratoconus patients.

Oxidative stress induces dysregulated autophagy in ... - EBSCOhost

 

search.ebscohost.com/login.aspx?direct=true&profile=ehost...site...

by R Shetty - ‎2017 - ‎Cited by 8 - ‎Related articles

Title: Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients. Language: English; Authors: Shetty, Rohit1. Sharma ...

[PDF]

Endocrine and Metabolic Pathways Linked to Keratoconus ...

 

https://dash.harvard.edu/bitstream/handle/1/27320192/4860577.pdf?sequence=1...

by TB McKay - ‎2016 - ‎Cited by 12 - ‎Related articles

May 9, 2016 - and inflammatory pathways in Keratoconus (KC), which is a corneal .... and increased oxidative stress and apoptosis36, which are both ...

Reactive oxygen species, oxidative stress, glaucoma and hyperbaric ...

 

https://www.sciencedirect.com/science/article/pii/S188842961730050X

by C McMonnies - ‎2018 - ‎Cited by 5 - ‎Related articles

This review examines the role of oxidative stress in damage to cells of the ..... retinopathy and age-related macular degeneration. as well as keratoconus, ...

Corneal oxidative damage in keratoconus cells due to decreased ...

 

www.jovr.org/article.asp?issn=2008-322X;year=2019;volume=14;issue=1;...

by SR Atilano - ‎2019 - ‎Related articles

Corneal oxidative damage in keratoconus cells due to decreased oxidant elimination from modified expression levels of SOD enzymes, PRDX6, SCARA3, ...

Genetic Polymorphisms of Catalase and Glutathione Peroxidase-1 in ...

 

ijph.tums.ac.ir/index.php/ijph/article/view/14927

by Y Davood - ‎2018 - ‎Related articles

Oct 7, 2018 - Keywords: CAT, GPX-1, Oxidative stress, Keratoconus, Polymorphism. Abstract. Abstract Background: Keratoconus (KC) is a degenerative eye ...

[PDF]

Evaluation of Antioxidant Enzymes in Keratoconus - Revistadechimie.ro

 

www.revistadechimie.ro/pdf/CANTEMIR%208%2016.pdf

by A CANTEMIR - ‎Cited by 3 - ‎Related articles

the effects of this disorder on antioxidant enzymes or the possible interventions at the oxidative stress level in keratoconus patients. Keywords: oxidative stress ...

Oxidative Stress in Keratoconus? - Northwest Life Science

 

https://www.nwlifescience.com/citations/54-nwk.../477-oxidative-stress-in-keratoconu...

nutrition glutathione GSH SOD lipid peroxidation MDA oxidative stress 8OHDG radiation urine rat 8OHDG01 DNA Damage Urine malondialdehyde ...

A new perspective on the pathobiology of keratoconus: interplay of ...

 

https://onlinelibrary.wiley.com/doi/full/10.1111/cxo.12025

by IMY Cheung - ‎2013 - ‎Cited by 38 - ‎Related articles

Jump to Oxidative stress in keratoconus - This product of oxidative DNA damage was restricted in normal corneas to superficial epithelial cells.135 ...

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