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OUR INGREDIENTS LIST

(And Their Functions in the Body)

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Vitamins A,C,E { Common and Powerful Antioxidant Nutrients to Combat the Oxidative Changes that Drive Keratoconus Progression}

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Zinc and Selenium { Have Antioxidant Functions and Serve as Cofactors in Collagen Synthesis To Support Repair of Corneal Tissue}

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Copper { An Extremely Important Micronutrient that is Hard to Obtain in Diet that Is Found to Help Interfere With the Inflammatory Changes That Make Keratoconus Worse}

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L-Glutathione { A Chemical that is Found in High Levels in the Normal Cornea that are in Very Low Amounts in Patients With Keratoconus}

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N-Acetylcysteine { Found to Be An Important Co-Factor in Corneal Protection Against Oxidative Damage}

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Scientific Studies Showing The Value of the Above Nutrients to Corneal Protection in Keratoconus

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Oxidative stress in keratoconus? - ‎Arnal - Cited by 95

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… response to oxidative stress in keratoconus corneal … - ‎Chwa - Cited by 72

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… in keratoconus corneas: evidence that oxidative stress … - ‎Kenney - Cited by 171

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Oxidative stress in keratoconus? - NCBI

 

https://www.ncbi.nlm.nih.gov/pubmed/21969298

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by E Arnal - ‎2011 - ‎Cited by 94 - ‎Related articles

Nov 4, 2011 - CONCLUSIONS: The increased levels of oxidative stress markers and the decreased antioxidant capacity and antioxidant defenses in KC corneas, as well as in the post-LASIK ectatic corneas, indicate that oxidative stress might be involved in the development of this disease and may provide new insights for its prevention ...

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Oxidative stress induces dysregulated autophagy in corneal ... - NCBI

 

https://www.ncbi.nlm.nih.gov/pubmed/28902914

by R Shetty - ‎2017 - ‎Cited by 8 - ‎Related articles

Sep 13, 2017 - Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients. Shetty R(1), Sharma A(2), Pahuja N(1), ...

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Oxidative Stress in the Pathogenesis of Keratoconus and Fuchs ...

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794834/

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by KA Wojcik - ‎2013 - ‎Cited by 70 - ‎Related articles

Sep 23, 2013 - UV produces reactive oxygen species (ROS) which render the cornea particularly susceptible to oxidative stress as a consequence of an imbalance between ROS production and antioxidant capacity of the cell [1]. Therefore, oxidative stress reflects increased production and/or impaired removal of ROS.

‎Abstract · ‎Introduction · ‎Oxidative Stress · ‎Conclusions

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Oxidative Stress May Contribute to Keratoconus - Review of Optometry

 

https://www.reviewofoptometry.com/.../oxidative-stress-may-contribute-to-keratoconu...

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Aug 28, 2018 - Oxidative Stress May Contribute to Keratoconus. Supplementing with zinc, copper and selenium could possibly augment current therapy.

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(PDF) Oxidative Stress in Keratoconus? - ResearchGate

 

https://www.researchgate.net/publication/51690964_Oxidative_Stress_in_Keratoconus

PDF | The purpose of this study was to establish the alterations of oxidative stress-related markers inkeratoconus (KC) corneas. A total of 6 healthy and 11 ...

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Oxidative Stress in Keratoconus? | IOVS | ARVO Journals

 

https://iovs.arvojournals.org/article.aspx?articleid=2186731

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by E Arnal - ‎2011 - ‎Cited by 94 - ‎Related articles

The increased levels of oxidative stress markers and the decreased antioxidant ... Keratoconus (KC) is a significant clinical problem worldwide and a leading ...

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Hypersensitive Response to Oxidative Stress in Keratoconus Corneal ...

 

https://iovs.arvojournals.org/article.aspx?articleid=2125588

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by M Chwa - ‎2008 - ‎Cited by 72 - ‎Related articles

purpose. It is unclear whether the oxidative damage found in keratoconus (KC) corneas results from innate defects of corneal fibroblasts or is due to excessive ...

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Sulforaphane protects rabbit corneas against oxidative stress injury in ...

 

https://www.spandidos-publications.com/ijmm/42/5/2315

by R Liu - ‎2018 - ‎Cited by 1 - ‎Related articles

Aug 10, 2018 - Keratoconus (KC) is the leading cause of eye blindness. ... Under oxidative stressconditions, Nrf-2 is dissociated from Keap1, constitutively ...

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Genetics, oxidative stress suspected causes of keratoconus - Healio

 

https://www.healio.com/.../genetics-oxidative-stress-suspected-causes-of-keratoconus

Primary Care Optometry News | COLUMBUS, Ohio — While the treatment of keratoconus is fairly straightforward, with well-fitted specialty lenses or corneal ...

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In vitro model suggests oxidative stress involved in keratoconus disease

 

https://www.nature.com › scientific reports › articles

by D Karamichos - ‎2014 - ‎Cited by 48 - ‎Related articles

Apr 9, 2014 - We aimed to identify oxidative stress levels between human corneal keratocytes (HCKs), fibroblasts (HCFs) and keratoconus cells (HKCs).

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Increased systemic oxidative stress in patients with keratoconus | Eye

 

https://www.nature.com › eye › clinical study

by I Toprak - ‎2014 - ‎Cited by 37 - ‎Related articles

Dec 6, 2013 - To establish the effect of systemic oxidative stress on the pathogenesis of keratoconusby measuring serum total oxidant status (TOS) and total ...[PDF]

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Tear Film and Serum Prolidase Activity and Oxidative Stress in ...

 

www.smo.org.mx/archivos/smonline/cornea/articulos/1019–1023.pdf

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prolidase activity (PA) between patients with keratoconus and healthy subjects. Also, we aimed to evaluate the serum oxidative stress level and the correlation ...

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Oxidative Stress in the Pathogenesis of Keratoconus and Fuchs ...

 

https://www.semanticscholar.org/.../Oxidative-Stress...Keratoconus.../db5a79e5fa3138fd...

Therefore, corneal cells are particularly susceptible to oxidative stress. ... Keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD) are multifactorial ...

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Evidence of Oxidative Stress in Human Corneal Diseases - Rajeev ...

 

https://journals.sagepub.com/doi/full/10.1177/002215540205000306

by R Buddi - ‎2002 - ‎Cited by 273 - ‎Related articles

Keratoconus corneas showed evidence of oxidative damage from cytotoxic byproducts generated by lipid peroxidation and the NO pathway. Bullous keratopathy ...

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Oxidative Stress and keratoconus : Keratoconus - Reddit

 

https://www.reddit.com/r/Keratoconus/comments/.../oxidative_stress_and_keratoconus...

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Feb 11, 2019 - 1 post - ‎1 author

Welcome to the largest Keratoconus support community on the web. Here you can share yourkeratoconus stories, ask for recommendations, ...

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Nrf2, a Potential Therapeutic Target against Oxidative Stress in ...

 

https://www.hindawi.com/journals/omcl/2017/2326178/

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by XF Liu - ‎2017 - ‎Cited by 3 - ‎Related articles

Sep 20, 2017 - A Nrf2-Keap1-dependent protective role against oxidative stress in ... as Fuchs endothelial corneal dystrophy (FECD) and keratoconus [23].

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Novel Assay Assessment of Oxidative Stress Biomarkers in Patients ...

 

https://www.tandfonline.com/doi/abs/10.1080/02713683.2017.1302592

by B Gulpamuk - ‎2017 - ‎Cited by 2 - ‎Related articles

Purpose: To investigate systemic oxidative stress by evaluating thiol–disulfide homeostasis using a novel automated homeostasis assay in keratoconus patients.

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